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Argemone mexicana (Mexican poppy, Mexican prickly poppy, cardo or cardosanto) is a species of poppy found in Mexico and now widely naturalized in the United States, India and Ethiopia. An annual herb with bright yellow sap, it is poisonous, but has been used medicinally by many people including those in its native area, the Natives of the western US and parts of Mexico. The seeds contain 22–36% of a pale yellow non-edible oil, called argemone oil or katkar oil, which contains the toxic alkaloids sanguinarine and dihydrosanguinarine. Four quaternary isoquinoline alkaloids, dehydrocorydalmine, jatrorrhizine, columbamine, and oxyberberine, have been isolated from the whole plant of Argemone mexicana. The Seri of Sonora, Mexico use the entire plant both fresh and dried. An infusion is made to relieve kidney pain, to help expel a torn placenta, and in general to help cleanse the body after parturition. When the Spanish arrived in Sonora they added this plant to their pharmacopia and called it cardosanto, which should not be mistranslated to blessed thistle (Cnicus benedictus). Use in Hispanic cultures includes as a sedative and analgesic tea, including for use to help alleviate migraine headaches. The seeds are taken as a laxative. The seed-pods secrete a pale-yellow latex substance when cut open. This argemone resin contains berberine and protopine, and is used medicinally as a sedative. Argemone mexicana is used by traditional healers in Mali to treat malaria. Katkar oil poisoning causes epidemic dropsy, with symptoms including extreme swelling, particularly of the legs.
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